Association of single nucleotide polymorphisms in toll-like receptors with acinetobacter baumanii infectionin a Chinese population

Background: during recent years,infection of acinetobacter baumanii showed a rapid growth in hospitals and community. toll-like receptors (tlrs) are the most important pattern recognition receptors,which play a critical role during recognizing invading pathogens by the natural immune system. our objective was to determine the associations of tlrs polymorphisms with the susceptibility to a. baumanii infection in a chinese population. methods: we carried out a case-control study,genotyping 13 polymorphisms of tlr-2,tlr-4,tlr-5 and tlr-9 genes on 423 a. baumanii-infected patients and 385 exposed controls. thirteen snps at the tlr-2 (rs3804099,rs7656411 and rs76112010),tlr-4 (rs1927914,rs10759932 and rs11536889),tlr-5 (rs1341987,rs1640827,rs1861172,rs2241097,rs5744174 and rs17163737) and tlr9 (rs187084) genes were analyzed. snp genotyping was performed using an improved multiplex ligation detection reaction (imldr) technique. results: the snp of tlr-9,rs187084,was related to a. baumanii-infection significantly under recessive model (g/g,to a/a + g/a,p = 0.0064,or = 0.59,95% ci = 0.40-0.86) after adjustment with age. besides,the haplotype gcg of tlr-4 was significantly associated with a. baumanii infection (p = 0.027). conclusion: tlr-4 and tlr-9 may be related to the susceptibility to a. baumanii infection in a chinese population. © 2016,iranian journal of public health. all rights reserved.