Lower serum levels of uric acid in uterine fibroids and fibrocystic breast disease patients in Dongying city,China

Background: increasing serum levels of uric acid (sua) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate sua. estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. the study aimed to explore sua among patients suffering from these diseases to enhance the hypothesis. methods: overall,1349 female participants were selected into three cases: case i having uterine fibroids (n=568),case ii having fibrocycstic breast disease (n=608) and case iii having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. based on health check-up data from 2011 to 2012,in dongying shengli oilfield central hospital,a cross-sectional study was conducted to examine the difference in sua between the case and control. we adjusted covariates by generalized linear regression mode. results: from 19 to 44 yr,sua of case i to case iii were lower than controls by 8.46 umol/l (p=0.011),5.88umol/l (p=0.014) and 9.39 umol/l (p=0.059),respectively. from 45-54 yr,no significant differences were between three cases and controls. in case i and its control: from 54-59 yr,differences were not significant; from 60 to 72 yr,sua in case i was lower than the control by 32.02umol/l (p=0.003). conclusion: participants of uterine fibroids and fibrocystic breast disease had a lower sua except the stage of menopause,which indirectly supported that estrogenic effect,may protectively decrease sua. © 2016,iranian journal of public health. all rights reserved.