effects of immunocytokine combined with cattle encephalon glycoside and ignotin on ctgf, ho-1 and nt-3 in patients with type 2 diabetic peripheral neuropathy

Background: this study was designed to explore the correlation of connective tissue growth factor (ctgf), heme oxygenase (ho-1), neurotrophic factors (nt-3) with type 2 diabetic peripheral neuropathy, as well as the changes af-ter immune cytokine alone and combined with cattleencephalon glycoside and ignotin treatment. methods: seventy-six patients with type 2 diabetes and peripheral neuropathy charged into people’s hospital of rizhaolanshan, china from 2014-2016 were selected. the severity of neuropathy was evaluated by tcss. pearson analysis was used to analyze the correlation between the degree of neuropathy and ctgf, ho-1 and nt-3. the pa-tients were randomly divided into control group and observation group, n=38. the control group accepted tgf-β1 treatment on the basis of controlling diet and blood sugar, while the observation group was treated with cattle enceph-alon glycoside and ignotin injection on the basis of control group. ctgf、ho-1, nt-3 concentration in the blood and nerve conductive velocity (ncv) were detected and analyzed before and after treatment. results: ctgf(r=-0.865), ho-1(r=-0.706), nt-3(r=-0.587) was negatively correlated with tcss scores. after treat-ment, the concentrations of ctgf、ho-1and nt-3 in the observation group were higher than the control group (p<0.05). in moderate and severe lesions, the concentrations of ctgf, ho-1and nt-3 in the observation group were higher than the control group (p<0.05). the conduction velocity of nerve increased with the increase of ctgf, ho-1 and nt-3 concentrations. the obvious effective rate and total effective rate of observation group were both higher than the control group. conclusion: immune cytokine tgf-β1 combined with cattle encephalon glycoside and ignotin injection could im-prove the contents of ctgf, ho-1 and nt-3, and be better to treat the peripheral neuropathy of type 2 diabetes.