insertion/deletion polymorphisms and serum angiotensinconverting enzyme levels in iranian patients with sarcoidosis

Background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who histopathologically diagnosed for sarcoidosis and 192 healthy age and sex-matched controls were recruited. pcr was used for detection of i/d polymorphism in ace gene. results: frequency of ii/id/dd genotype in sarcoidosis disease was 17%, 35.5%, and 47.1%, respectively. the fre-quency of d allele was 0.65. a significant association between i/d genotypes and mean of sace level was seen (dd=85.2±22.9, p<0.001). more frequent genotype in sarcoidosis patients was dd (47%), id genotype (45.9%) was found more in controls. logistic regression analysis adjusting age and sex showed that id to ii (or=0.35, 95%ci=0.17-0.73, p=0.005) and dd to ii (or=2.11, 95%ci=0.98-4.54, p=0.05) could be considered as a predictor factor for the disease activity. no significant model for men in sarcoidosis group was seen, while women with ii/id were associated with a reduced risk for the disease. conclusion: although more regional studies with appropriate statistical scale must be done to provide a better diag-nosis and prognostic tool for this disease, this study demonstrates that id and dd genotype could be predictive fac-tors for sarcoidosis.