association of sirt6 gene polymorphisms with human longevity

Background: we aimed to identify the role of sirt6 gene polymorphism rs350846 in human longevity. methods: sirt6 c/g genotypes were determined using taqman snp genotyping assays in 169 long-lived inhabi-tants (lg group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family history of exceptional longevity. statistical analysis was conducted using spss 16.0. results: bmi and tg level were lower in the longevity than in the two control groups, while serum ldl-c and hdl-c and sbp and dbp levels in long-lived individuals were higher than in the two control groups (p<0.01). the waist circumference was obviously different (p=0.001) among the three groups, with the maximum observed in the external group. no statistically significant differences of the gender fbg and tc were seen in long-lived individuals than in the two control groups. significant genotype differences existed among the different groups except for the longevity and internal control group. the frequency of the minor allele-c was 0.319. the minor allele frequency of rs350846 in sirt6 was much higher in the external control than in the other groups. bmi, sbp and hdl-c displayed significant effect on longevity. conclusion: the c allele of rs350846 in sirt6 gene, cc and cg genotypes as well as bmi, systolic pressure and hdl-c are associated with longevity. further studies are needed to validate our results.