association of cox-2 promoter polymorphisms 765g/c and-1195a/g with migraine

Background: migraine is a common debilitating primary headache disorder with current head pain attacks, which contributes to physical activity dysfunctions in chronic pain phase. pge2 and pgi2 are two important prostaglandins synthesised by cox-2 enzymes, involved in migraine pain signals. cox-2 modulation is essential in treatment and pathogenesis of migraine. this study aimed to investigating the association between cox-2 gene polymorphisms with the risk of migraine susceptibility in migraine patients with related and unrelated parents. methods: this case- control study was based on 100 migraine patients and 100 non-migraine subjects in bushehr province, iran in 2013. genomic dna of blood samples was extracted and genotyping of cox-2-765g>c (rs20417) and cox-2-1195a>g (rs689466) gene variants was investigated by pcr-rflp method. statistical analyses were ac-complished using the spss software package. results: there was a significant differences in the frequencies of the cox-2-765g>c and cox-2-1195a>g geno-types between migraine patients and controls (p≤0.05). conclusion: cox-2-765cc, cox-2-765cg, cox-2-1195gg and cox-2-1195ag genotypes can increase the risk of migraine significantly. as the first study in iran, we are hopeful to achieve greater results about the relevancy of cox-2 gene, migraine and pain signals pathway by repeating these experiments on more samples.