The Effect of Conjugated Linoleic Acids, Vitamin E and Their Combination on Lipid Peroxidation in Active Rheumatoid Arthritis

Background: reactive oxygen species (ros) have important role in the etiology and pathogenesis of rheumatoid arthritis(ra). we investigated the effect of conjugated linoleic acids (clas) and vitamin e on lipid peroxidation.methods: in a randomized, double-blind placebo, controlled, clinical trial 87 patients with active ra were enrolled. they weredivided into 4 groups, received one of the following daily supplement for 3 months; 1- group c: 2.5gr cla, that contained 2 gr50:50 mix of cis 9-trans11 and trans 10-cis 12 clas, 2- group e: 400mg vitamin e, 3- group ce: clas plus vitamin e, 4- group p:placebo. after supplementation glutathione peroxidase (gsh-px) level increased in c, e and ce groups, ce group had lowergsh-px than p group(p. 0.05).results: glutathione reductase (gr) increased in ce, c and p groups. catalase increased in all groups, but enhancementwas significant in c and ce. superoxide dismutase (sod) decreased in e and c (p. 0.05). catalase and sod did not showsignificant differences between groups. malondialdehyde (mda) decreased significantly in all groups but this decrease wasonly significant in ce in comparison with other groups.conclusion: clas might be useful in reducing oxidative stress in ra