Tc1 Cells Percentage in Patients with Cutaneous Leishmaniasis before and after Treatment with Glucantime

Background: various responses and different prognosis to specific treatment in different patients from one hand , andimportance of ifn-y produ cer cells on the other hand impressed us to study tcl. methods: the stud y was conducted inghaem medical center and bu-ali research institute, mashhad univ ersity of medical scien ces, iran from 2001 to 2002 .lymphocytes of 36 patients were counted and cultured . percentage of different respon sible immunity cells in 29 patients,were determined by flow cytom etry system before and after medication with gjucantim e (im) . patients who showedimprovement after the tre atment were put into group i and those who did not recover were labeled group 2. in this self-controlclinical trial , sampling method was consecutive non-probability and the results were analyzed by t-test consequently.results: the percentage of tc i cells showed a significant incre ase despite of being stimulated with phorpol-mristate-acetateepma) amon g the whole studied patients and group i (p= 0.069 and p= 0.040 , respectively). while no significantchange was observed amon g patients in group 2. conclusion: this verifies the influen ce of tc i cells for the treatment ofpatients with cl and perh aps the role of glucantime in improving the cell immunity response through increa sing such cells.