The Effect of CaNa2-EDTA on Metabolism of Zinc and Carbohydrate as well as Some Biochemical Factors in Experimental Diabetes

Background: to investi gate the effect of cana2-edta and experimental diab etes (lodm) on zinc and carbohydrate metabolismand the activities of got, gpt and alkaline phosphatase. methods: forty male norm al albino (wist ar) rats of 8weeks of age were fed with a basal diet. twenty rats were then intraperitoneally injected with alloxan to induce diabetes.then after one week ten rats from each group (n= 20) were admini strated intraperitoneally with cana 2-edta for furtherthree weeks. body weight gain and food intake were recorded regularly. on day 2 1 animals were killed and blood gluco se,serum and tissues zinc concentrations, liver glycogen contents, serum transaminase enzymes (got, gpt) , and serum alkalinephosphatase activities were determined. results: the administration of cana2-edta signifi cantly altered body weightgain, food intak e and serum zinc concentration of either diabetic or non-diabet ic animals. both diabetic and non-diabeticrats given cana2-edta had higher blood glucose than their controls. liver glycogen was also found to be higher incana2-edta non-diabetic rats than their controls. cana2-edta also led to increa sing of got and gpt, and decreasingserum alkaline phosphatase. conclusion: to conclude, the present study demonstrates that cana2-edta had an effect onthe previous parameters. therefore it was appeared that cana2-edta resulted in the development of severe diabetes.