Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis

Background: as a dna repair protein, flap endonuclease 1 is a key enzyme in maintaining genomic instability and preventing carcinogenesis. two single nucleotide polymorphisms (snps), -69g>a and 4150g>t are associated with dna damage. this meta-analysis is to evaluate the genetic effects of fen1 gene snps (-69g/a and 4150g/t) and the susceptibility to diseases, including glioma risk, breast cancer, lung cancer, keratoconus (kc) and fuchs’ endothelial corneal dystrophy (fecd).methods: a literature search of pubmed and embase was conducted to identify all eligible published studies. five case-control studies were included with a total of 5612 cases and 6703 controls in this meta-analysis. crude odds ratios (ors) with their corresponding confidence intervals (95%ci) were used to assess the strength of the association.results: the fen1 -69g/a and 4150g/t polymorphisms were significantly associated with the disease risk. our meta-analysis showed the fen1 -69gg genotype was correlated to increase risk for the contained diseases compared with the -69ag genotype (or=0.77, 95%ci=0.71~0.83). moreover, the fen1 4150gg genotype could increase diseases risk compared with the 4150tg genotype (or=0.81, 95%ci=0.75~0.87).conclusion: the variant genotypes of the fen1 -69g/a and fen1 4150g/t polymorphisms may be associated with diseases susceptibility. however, more studies are needed to detect the disease risk in different ethnic populations