Effects of Anti-Mosquito Salivary Glands and Deglycosylated Midgut Antibodies of Anopheles Stephensi on Fecundity and Longevity

With the aim of controlling malaria by reducing vector population, the effects of antibodies produced against salivaryglands and deglycosylated midgut antigens of anopheles stephensi mosquitoes on fecundity and longevity of the same specieswere tested. three deglycosylated preparations of midgut and two preparations of salivary glands were produced, conjugatedwith aluminum hydroxide gel, and subcutaneously injected to shoulders of to (turner out-bred) mice. after 4 immunizationsand assurance of enough antibody production against utilized antigenic suspensions, effects of blood feedingon immunized and control mice were assayed. insoluble preparation of midgut showed the strongest effect with 23.5% reductionin egg laying, and increasing death rate of vectors in third day after feeding. no significant reduction in fecundity orsurvivorship was seen with other preparations. anopheles midgut insoluble antigens are potential candidates for designingvaccines against malaria vectors and further investigations need to be done to find effective antigens and the best way oftheir use.