Genetic of Alzheimer's disease: A narrative review article

Background: alzheimer's disease (ad) is one of the most common problems for old peoples. etiology of ad is not clear,but genetic factors play a major role in determining a person's risk to develop ad. twin and family studies confirm that ad has a genetic basis.ad genetics has been split into two broad categories: early-onset and late-onset. eo-ad cases are inherited in an autosomal dominant pattern. in this form,dominant mutations in genes like app,psen-1 and psen-2 associated with ad. this study aimed to consider the role of genetic in ad. method: at the first,most of the references in relation with genetic basis of ad searched from the following websites: pubmed,science direct,wiley & sons (1995-2014). then,the most common genes and their affects described briefly. results: aging is the most obvious risk factor for developing ad. there is a genetic basis for ad,of course this relation is not complete but it is significant. conclusion: more than thousand genes studied in relation with alzheimer's disease. against the improvements in understanding different aspects of ad,the accurate genetic foundation of ad remain unclear. © 2015 iranian journal of public health. all rights reserved.