Predictive power of ETRE polymorphism and Katg463 mutation to INH-resistance of M.Tuberculosis

Background: the miru-vntr polymorphism and katg463 mutation are used to genotype the mycobacterium tu-berculosis,but the correlation between them and inh-resistance were unknown. this study was aimed to explore whether etre polymorphism and katg463 mutation could predict the inh-resistance,and the relationship between etre polymorphism and katg463 mutation. methods: the etre,katg463 mutation and drug resistance information of 109 m. tuberculosis strains were collected from online public database. we constructed the predictive diagnostic tool of etre polymorphism and katg463 mu-tation. chi-square test was used to analyze the relationship between etre polymorphism,katg463 mutation and inh-resistance. roc curve analysis and z-test were used to evaluate the predictive ability of etre and katg463. the relationship between etre polymorphism and katg463 mutation was analyzed with spearman correlation analy-sis. results: the mutation rate of katg463 was 27.50%,and the h value of etre polymorphism was 0.67. katg463 mu-tation was associated with inh resistance (or=3.72). the inh drug resistance rate in vntr≧5 group was 3.43 times higher than that in vntr≦3 group (χ2=24.77，p<0.01),and there was no significant difference of inh re-sistance between the vntr=4 group and vntr≦3 group. the areas under the roc curve of two loci prediction diagnostic tools were 0.64 and 0.70 respectively. the katg463 mutation was significantly related to the etre poly-morphism（r=0.79,p<0.01). conclusion: both katg463 mutation and the etre polymorphism can predict the inh-resistance of tuberculosis. the katg463 mutation was associated with etre vntr polymorphism. © 2015,iranian journal of public health. all rights reserved.