Does Supplementation With Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?

Background: animal studies have shown antioxidant effects of royal jelly (rj) and its effect on insulin resistance as the most common complication of type 2 diabetes. this study was conducted to determine the effect of rj intake on serum total antioxidant capacity,malondialdehyde and insulin resistance in t2dm. methods: in this randomized controlled trial,forty-six type 2 diabetic patients,aged 25-65 years,with bmi of 20-30 kg/m2,and hba1c of 6-8% were included. the patients were randomly assigned to receive 1000 mg of rj supplement or placebo,3 times daily for 8 weeks. homa-ir,anthropometric measurements,fasting blood glucose,serum insulin,total antioxidant capacity and malondialdehyde level were measured. results: in comparison with placebo,homa-ir decreased (p=0.015) while serum total antioxidant capacity increased significantly in rj group (p=0.016). no significant difference was detected for serum insulin and mda in two groups. conclusions: rj intake may have favorable effects on serum tac and homa-ir in diabetic patients. © 2015,iranian journal of public health. all rights reserved.