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The Association Between Ptpn22 Genetic Polymorphism and Juvenile Idiopathic Arthritis (Jia) Susceptibility: An Updated Meta-Analysis
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نویسنده
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Di Y. ,Zhong S. ,Wu L. ,Li Y. ,Sun N.
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منبع
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Iranian Journal Of Public Health - 2015 - دوره : 44 - شماره : 9 - صفحه:1169 -1175
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چکیده
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Background: limited studies have focused on the association between the protein tyrosine phosphates non-receptor type 22 (ptpn22) genetic polymorphisms and juvenile idiopathic arthritis (jia) susceptibility in different populations,but the results were inconclusive. therefore,this meta-analysis of ptpn22 polymorphism (1858 c>t) was per-formed to get a precise systematic estimation. the rs number of the ptpn22 polymorphism (1858 c>t) is 4. methods: a systematic literature search strategy was carried out using english databases (pubmed,embase.) for the eligible studies. we ultimately identified 11 records from 10 articles involving the relationship between ptpn22 genet-ic polymorphisms and jia risk from pubmed and embase databases. overall,4552 cases and 10161 controls were investigated in this study to evaluate the association between ptpn22 (c allele vs. t allele) genotype and jia suscepti-bility. results: analysis using random effects model showed an increased risk of jia with t allele of rs2476601 vs. a allele (p<0.001). subgroup analysis suggested that the ptpn22 polymorphism (1858c>t) was significantly associated with jia risk in america population (or=1.52,95%ci:1.30-1.78). additionally,the subgroup analysis also showed that the associations were still significant in case number more than 500 (or=1.38,95% ci: 1.04-1.83),while in the case num-ber less than 500 was or=1.55,95% ci: 1.39-1.72. conclusions: snps of ptpn22 (1858c>t) showed an increased risk of developing jia. © 2015,iranian journal of public health. all rights reserved.
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کلیدواژه
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Jia; Juvenile Idiopathic Arthritis; Meta-Analysis; Phosphates Non-Receptor Type 22; Polymorphism; Ptpn22
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آدرس
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Dept. Of Rheumatism Immunity, China, Dept. Of Rheumatism Immunity, China, Dept. Of Rheumatism Immunity, China, Dept. Of Rheumatism Immunity, China, Dept. Of Rheumatism Immunity, China
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Authors
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