The association between PTPN22 genetic polymorphism and Juvenile Idiopathic Arthritis (JIA) susceptibility: An updated meta-analysis

Background: limited studies have focused on the association between the protein tyrosine phosphates non-receptor type 22 (ptpn22) genetic polymorphisms and juvenile idiopathic arthritis (jia) susceptibility in different populations,but the results were inconclusive. therefore,this meta-analysis of ptpn22 polymorphism (1858 c>t) was per-formed to get a precise systematic estimation. the rs number of the ptpn22 polymorphism (1858 c>t) is 4. methods: a systematic literature search strategy was carried out using english databases (pubmed,embase.) for the eligible studies. we ultimately identified 11 records from 10 articles involving the relationship between ptpn22 genet-ic polymorphisms and jia risk from pubmed and embase databases. overall,4552 cases and 10161 controls were investigated in this study to evaluate the association between ptpn22 (c allele vs. t allele) genotype and jia suscepti-bility. results: analysis using random effects model showed an increased risk of jia with t allele of rs2476601 vs. a allele (p<0.001). subgroup analysis suggested that the ptpn22 polymorphism (1858c>t) was significantly associated with jia risk in america population (or=1.52,95%ci:1.30-1.78). additionally,the subgroup analysis also showed that the associations were still significant in case number more than 500 (or=1.38,95% ci: 1.04-1.83),while in the case num-ber less than 500 was or=1.55,95% ci: 1.39-1.72. conclusions: snps of ptpn22 (1858c>t) showed an increased risk of developing jia. © 2015,iranian journal of public health. all rights reserved.