Effect of Acute Paracetamol Overdose on Changes in Serum Electrolytes

Paracetamol is a widely available over-the-counter analgesic, which is frequently taken in overdose. it has some prostaglandin synthesis inhibitory actions. in overdose nsaids, which also inhibit prostaglandin synthesis, can cause dose-dependent hypokalaemia, increase fractional excretion of potassium and sodium retention due to renal vasoconstriction. therapeutic doses of paracetamol have no effect on potassium levels or excretion. the aim of this study was to study electrolyte changes in patients with paracetamol overdose. the study was retrospective, conducted on 60 patients with paracetamol overdose aged 16-65y admitted to the toxicology ward of the royal infirmary of edinburgh from 2000-2003. we excluded the effect of other drugs known to be nephrotoxic by history. the hospital laboratory system was used to extract biochemistry results taken at admission (4-6 hours after ingestion), and again approximately 18 hours later. changes in electrolytes were correlated to admission paracetamol levels. the results showed a significant negative correlation between admission paracetamol level (4-6 hr level) and fall in serum potassium: serum k+ change (y= -0.002lx + 0.0051, r2 = 0.19, p< 0.01). there was no change in serum sodium or creatinine. the mean fall in serum k+ in the quartile with highest paracetamol concentrations (mean 256 mg/1) was -0.65 ±0.16 mmol/1. in conclusion, paracetamol overdose is associated with hypokalaemia in proportion to the dose ingested, suggesting a specific renal effect of paracetamol in overdose. these findings could be consistent with increasing aldosterone action on the distal tubules as renal perfusion falls due to paracetamol-induced renal vasoconstriction.