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Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats.
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نویسنده
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Fakher SH. ,Djalali M. ,Tabei SMB. ,Zeraati H. ,Javadi E. ,Sadeghi MR. ,Mostafavi E. ,Fatehi F.
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منبع
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iranian journal of public health - 2007 - دوره : 36 - شماره : 2 - صفحه:58 -63
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چکیده
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Background: to assess the effect of supplementation with vitamins a, e and c and (omega)-3 fatty acids on lipid peroxidation in streptozotocin (stz) induced diabetic rats. methods: sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin a, e as well as c supplementation and diabetic with (omega)-3 fatty acids supplementation. after four weeks oftreatment the rats were anesthetized and malondialdehyde (mda) levels were investigated in blood samples, liver and heart homogenate.results: in diabetic rats mda level in plasma, liver and heart was significantly more elevated than normal control rats (p<0.05). vitamin a, e and c supplementation caused significant decrease in plasma, liver and heart mda (p< 0.05). a significant decrease in heart mda (p< 0.05) was observed in diabetic rats with (omega)-3 fatty acids supplementation.conclusion: supplementation of vitamin a, e and c and (omega)-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes .
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کلیدواژه
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Vitamin C ,Vitamin E ,Vitamin A ,Omega3 fatty acid ,Malondialdehyde.
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آدرس
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tehran university of medical sciences tums, School of Public Health and Institute of Public Health Research , Dept of Nutrition and Biochemistry , ایران, tehran university of medical sciences tums, School of Public Health and Institute of Public Health Research , Dept of Nutrition and Biochemistry , ایران, shiraz university of medical sciences, Faculty of Medicine , Dept of Biochemistry , ایران, tehran university of medical sciences tums, School of Public Health and Institute of Public Health Research , Dept of Epidemiology and Biostatistics , ایران, tehran university of medical sciences tums, Research Center of Endocrinology , ایران, Avicenna Research Institute, Reproductive Biotechnology Research Center , ایران, tehran university of medical sciences tums, Faculty of Medicine , Dept of Pathology , ایران, tehran university of medical sciences tums, School of Public Health and Institute of Public Health Research , Dept of Nutrition and Biochemistry , ایران
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پست الکترونیکی
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jalalimahmoud@hotmail.com
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Authors
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