Invitro Antitrichomonas Activity of Allium hirtifolium (Persian Shallot) in Comparison with Metronidazole

Trichomonas vaginalis infection is a sexually transmitted infection causing vaginitis and acute inflammatory disease of thegenital mucosa. although metronidazole resistance in t. vaginalis is well documented, the only drug approved for thetreatment of trichomoniasis in some countries is metronidazole. genus allium plants including garlic; shallot and onionhave had an important medicinal role for centuries. some study have proven antibacterial, antifungal, antiviral, antiprotozoaland antihelmintic properties of genus allium plants. at first pshe and psde ( persian shallot hydroalcoholic anddichlromethanic extract) was prepared in ethanol/water (50:50) and dichlromethane respectively at cool temperature (10؛c).genus allium plants extracts were shown to decrease the oxygen uptake, reduce the growth of the organism, inhibit the synthesisof lipids, proteins and nucleic acids and damage membranes. in this study the minimal inhibitory concentrations(mics) of pshe, psde and metronidazole respectively were 10, 5 and 2µg/ml. persian shallot inhibited growth of t.vaginalis at low concentrations and in short times, therefore this plant have some antitrichomonas components (includingallicin, ajoene and other organosulfides) that antimicrobial properties of these was proven.