Moxifloxacin induced seizures - A case report

Background: a 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. this patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage,with impaired renal function and liver function,but without history of seizures. moxifloxacin was discontinued and switched to cefuroxime. the patient remained seizure-free at discharge four days later. the naranjo adverse drug reaction probability scale score was 4,indicating a possible adverse reaction to moxifloxacin. the potential risk factors related to moxifloxacin-induced seizures are discussed. it highlights that preexisting central nervous system disease,elderly female with lower bodyweight and severe renal impairment may be the risk factors involved in moxifloxacin-induced seizures. © 2014,iranian journal of public health. all rights reserved.