Effect of vitamin E and metformin on fatty liver disease in obese children-randomized clinical trial

Background: we evaluated the effect of vitamin e and metformin on fatty liver disease in obese children.methods: this interventional study has been done on 119 children with non-alcoholic fatty liver disease (based on sonography results). patients were divided into four treatment groups; they received metformin 1gr daily (age< 12 years),metformin 1.5 gr daily (age> 12 years),vitamin e 800 u daily and vitamin e 400 u daily. liver sonography was performed for patients for two periods of two months. this trial was registered in iranian registry of clinical trials (irct),no.irct2013021012421n1.results: the study group comprised 119 individuals (62 females,57 males). the mean age was 10± 3.19 yr. there was no significant difference in terms of sex and bmi between the groups. overall liver sonography showed normal liver in 66 patients (55.46%),66.63% after two months and 33.37% after four months. after two months,the most therapeutic response observed in the group which received vitamin e 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin e 400 u daily (14.3%). after four months,the greater response was seen in vitamin e 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%).conclusion: in comparison with metformin,vitamin e is more influential in remission; however both are efficient in treatment of fatty liver. vitamin e 400 u daily responses better in four-month treatment. © 2014,iranian journal of public health. all rights reserved.