A randomized,controlled trial of levonorgestrel vs. the yuzpe regimen as emergency contraception method among Iranian women

Background: we aimed to compare acceptability of levonorgestrel with the yuzpe regimen among iranian women based on their side-effects and resulting changes in the amount and pattern of menses. methods: five hundred twenty nine participants aged 15-49 having regular menses and one act of unprotected inter-course within 72 h were included in the double-blind,controlled trial in 2006-2007 and randomly assigned into lng (n=263) and hd (n=266) groups,receiving levonorgestrel 0.75 mg given 12 h apart and ethinyl estradiol 100 μg plus 0.5 mg levonorgestrel 0.5 mg repeated after 12 h,respectively. results: the participants receiving levonorgestrel experienced significantly lower side-effects in the case of nausea,vomiting,and dizziness (p<0.05). the changes occurred in the amount and pattern of menses were the same for both groups (p>0.05). no significant difference was observed between the efficiencies of the treatments. conclusion: significantly lower side-effects of levonorgestrel can be considered as greater acceptability and translat-ed to higher efficiency.