Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different Basic Renal Functions: A Meta-Analysis

Background: uric acid level has shown a certain relationship with the incidence of post-contrast acute kidney injury (pc-aki), whereas it remains controversial whether hyperuricemia can function as a predictor of pc-aki in patients with different basic creatinine serum level. the present meta-analysis aimed to investigate whether hyperuricemia is an independent risk factor for pc-aki and to explore the relationship between hyperuricemia and basic renal function.methods: relevant studies were retrieved via searching in pubmed, embase, cochrane library, and wan fang electronic databases from inception to jan 2022. only studies published in english and chinese lan-guages were selected.results: overall, 11892 patients from 15 studies were included. the results of the pooled analysis revealed that the incidence of pc-aki was significantly higher in the hyperuricemia group than that in the normour-icemic group (20.62% vs. 13.05%). hyperuricemia was associated with an increased risk of the incidence of pc-aki (odds ratio (or): 2.48 [95% confidence interval (ci): 1.77-3.46%]). the pooled ors for mortality and incidence of undergoing renal replacement therapy were 2.33 (95% ci:1.81-3.00) and 8.69 (95% ci:3.22-23.44%), respectively. comparatively, the pre-existing renal dysfunction subgroup had a lower relative risk in the hyperuricemia population.conclusion: hyperuricemia was found to be significantly associated with the incidence of pc-aki. the ef-fect of serum uric acid level on the incidence of pc-aki was higher in patients with normal renal function, which could lay a foundation for the establishment of individualized schemes to prevent pc-aki by urate-lowering therapy.