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A Disintegrin and Metalloprotease 10 Expressions Modulate Potential Metastatic and Thrombus Formation in Pancreatic Carcinoma
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نویسنده
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yu miao ,chen quan ,li qin ,teng yunfei ,xiao lin ,yang guang ,ouyang chenxi ,abdalla ahmed mohammed elamin
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منبع
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iranian journal of public health - 2022 - دوره : 51 - شماره : 8 - صفحه:1778 -1789
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چکیده
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Background: clinical investigations repurposing a disintegrin and metalloproteases 10 (adam10) as metastat-ic and thrombus marker have achieved encouraging results, but the mechanism behind this association remains unclear.methods: this study was carried out in ningxia and wuhan, china from 2017 to 2021. the effects of ad-am10 expression on the metastatic and thrombus-associated genes: tissue factor (tf), p-selectin glycoprotein ligand-1 (psgl-1), cathepsin g (ctsg) and mucin 1 (muc1) were examined by immunofluorescence, qrt-pcr and western blotting analysis. metastatic and thrombotic behaviors were evaluated using nodscid mouse model.results: the adam10 expression controlled the migration and invasion of pancreatic carcinoma cell-1(panc-1), and significantly regulated the metastatic and thrombus-associated genes (p＜0.05). adam10 and muc1 were regulated and aberrantly expressed by a dependent mechanism. moreover, adam10 expression induced the progression of adenocarcinoma cells and thrombus formation in vivo.conclusion: regulation of adam10 expression in cancer cells might effectively pave the way for a more po-tent anti-metastatic and anti-thrombotic approach and could regulate the invasion and migration of cancer cells.
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کلیدواژه
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ADAM10 protein; Metastasis; Thrombosis
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آدرس
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general hospital of ningxia medical university, department of vascular surgery, China, gansu provincial hospital, department of vascular surgery, China, huazhong university of science and technology, union hospital, tongji medical college, department of vascular surgery, China, huazhong university of science and technology, union hospital, tongji medical college, department of vascular surgery, China, huazhong university of science and technology, college of life science and technology, department of biomedical engineering, China, huazhong university of science and technology, college of life science and technology, department of biomedical engineering, China, chinese academy of medical sciences and peking union medical college, fuwai hospital, national center for cardiovascular disease, department of vascular surgery, China, huazhong university of science and technology, college of life science and technology, department of biomedical engineering, China. university of bahri, college of applied science, department of biochemistry, Sudan
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پست الکترونیکی
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ahmedbio1@outlook.com
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Authors
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