Association of Interleukin 10 (IL-10) Gene Polymorphism (819T > C) with Susceptibility to Acute Myeloid Leukemia: A Meta-Analysis

Background: studies reported an association between interleukin (il)-10 -819t>c polymorphism and the risk of developing acute myeloid leukemia (aml), however due to inconsistency among these results, relationship between il-10 -819t>c polymorphism and aml remained unclear. we herein performed this meta-analysis to investigate the association of il-10 -819t >c polymorphism with the risk of aml. methods: a systematic search through pubmed, embase, scopus, cochrane library and opengrey was performed from inception to jan 2021. odds ratios (or) with their corresponding 95% confidence intervals (ci) for five possible genetic models were calculated. heterogeneity was assessed using the cochran q test and the i2 statistic. a total of 404 aml cases and 635 healthy controls were included in our meta-analysis. results: our results indicated no statically significant association between il-10 -819t>c polymorphism and the risk of developing aml; dominant model (or=0.87, 95% ci=0.42–1.81); recessive model (or=1.17, 95% ci = 0.43–3.16); allelic model (or=1.00, 95% ci=0.54–1.88); cc vs. tt (or=1.00,95% ci=0.30–3.36); and tc vs. tt (or=0.80, 95%ci =0.46–1.37). conclusion: il-10 -819t > c polymorphism is not associated with the risk of aml. however further studies focusing on other parameters such as sex, gene-gene interactions and environmental factors are required to reveal the true association of il-10 -819t > c polymorphism with aml.