Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population

Background: as an infectious disease closely related to mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. methods: between january 2016 and november 2018, a hospital-based case-control study was conducted. this epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in elovl2 gene were detected by sanger sequencing. results: stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, p = 0.030), genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, or = 1.414, 95% ci: 1.036-1.929, p < 0.05). the polymorphism of rs2236212 between male tb patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, or = 0.507; 95% ci: 0.262-0.981, p < 0.05). conclusion: the rs3798719 of elovl2 gene may be associated with susceptibility to tb in female population and the rs2236212 of elovl2 gene may be associated with tb incidence in male patients.