Association between Meteorological Parameters and Hand, Foot and Mouth Disease in Mainland China: A Systematic Review and Meta-Analysis

Background: this study reports a systematic review of association between meteorological parameters and hand, foot and mouth disease (hfmd) in mainland china. methods: using predefined study eligibility criteria, three electronic databases (pubmed, web of science, and embase) were searched for relevant articles. using a combination of search terms, including “hand foot and mouth disease,” “hfmd,” “meteorological,” “climate,” and “china,” after removal of duplicates, our initial search generated 2435 studies published from 1990 to december 31, 2019. from this cohort 51 full-text articles were reviewed for eligibility assessment. the meta-analysis was devised in accordance with the published guidelines of the cochrane collaboration and preferred reporting items for systematic reviews and meta-analysis (prisma). effect sizes, heterogeneity estimates and publication bias were computed using r software and review manager software. results: the meta-analysis of 18 eligible studies showed that the meteorological parameters played an important role in the prevalence of hfmd. lower air pressure may be the main risk factor for the incidence of hfmd in chinese mainland, and three meteorological parameters (mean temperature, rainfall and relative humidity) have a significant association with the incidence of hfmd in subtropical regions. conclusion: lower air pressure might be the main risk factor for the incidence of hfmd in chinese main-land. the influence of meteorological parameters on the prevalence of hfmd is mainly through changing virus viability in aerosols, which may be different in different climate regions. in an environment with low air pressure, wearing a mask that filters the aerosol outdoors may help prevent hfmd infection.