Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients

Background: the upregulation of mirna-155 (mir-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (npc). however, the profile of mir-155 in vietnamese npc patients has not been investigated. the current study aimed to evaluate the mir-155 expression and assess whether mir-155 is a potential biomarker for diagnosis of npc in vietnamese patients. methods: in current case-control study, total of rna was isolated from 60 biopsy npc samples and 60 non-cancerous swab samples were analyzed by reverse-transcription pcr, qualitative real-time pcr. results: the frequency of mir-155 detection were 78.33%, 15.0% in npc and non-cancerous samples (p<0.05), respectively. the mir-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample. conclusion: taken together, mir-155 in npc was upregulated. it may serve as a potential biomarker for npc in the vietnamese population.