Therapeutic and Diagnostic Value of Caspase-12 and Study of Growth Differentiation Factor-15 in Patients with Acute Myocardial Infarction

Background: to investigate the therapeutic and diagnostic value of caspase-12 and study of growth differentiation factor-15 (gdf-15) in patients with acute myocardial infarction (ami).methods: overall, 78 patients with ami admitted to weifang people's hospital brain hospital, weifang, china from apr 2016 to apr 2019 were enrolled as ami group. seventy-five non-ami people undergoing physical examination during the same period were enrolled as non-ami group. the expression levels of caspase-12 and gdf-15 were detected and compared. the correlation between the expressions of gdf-15, caspase-12 and clinical characteristics and efficacy was detected. single and combined detection of gdf-15 and caspase-12 were performed analyze their role in the early diagnosis, the prediction of efficacy, and the guidance of clinical therapy. results: after treatment, the levels of gdf-15 and caspase-12 in ami group were significantly lower than those before treatment (p<0.001). the expression levels of gdf-15 and caspase-12 were significantly correlated with blood pressure (p<0.05). the expression levels of gdf-15 and caspase-12 were significantly negatively correlated with clinical efficacy in ami group. the diagnostic value of combined detection of gdf-15 and caspase-12 was higher than that of single diagnosis. the levels of serum caspase-12 and gdf-15 proteins were significantly up regulated in ami patients. with the better therapeutic effect, the levels of serum caspase-12 and gdf-15 proteins decreased significantly. conclusion: the levels of serum caspase-12 and gdf-15 proteins may be a key indicator in the clinical diagnosis of acute myocardial infarction and may be used to guide the treatment of ami patients and predict the therapeutic efficacy.