Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis

Background: the gene polymorphisms in microrna might relate to susceptibility of type 2 diabetes mellitus (t2dm). however, the results of existing studies were inconsistent and obscure. to investigate the precise associations between microrna gene polymorphisms and t2dm risk, the present meta-analysis was performed. methods: the literatures were searched from four electronic databases, pubmed, embase, cnki and wan-fang. subsequently, odds ratios (ors) and the corresponding 95% confidence intervals (cis) were both used to evaluate the associations between two single nucleotide polymorphisms (snps) (microrna146a rs2910164 (g>c), microrna124a rs531564 (c>g)) and risk of t2dm in asian population. results: totally, there were 4 studies included in our present analysis in the language of english and chinese. there were partly significant associations between susceptibility of t2dm and snps (microrna146a rs2910164 (g>c), microrna124a rs531564 (c>g)). the g allele in microrna146a rs2910164 (g>c) and c allele in microrna124a rs531564 (c>g) both presented remarkably reduced risk of t2dm when compared with the healthy population. conclusion: the microrna146a rs2910164 (g allele) and microrna124a rs531564 (c allele) might function as protective factors in the pathogenetic process of t2dm in asian population.