Expressions of miR-21 and miR-210 in Breast Cancer and Their Predictive Values for Prognosis

Background: we aimed to investigate the expressions of mir-21 and mir-210 in the breast cancer tissue and their correlation with clinicopathological features and prognosis. methods: a retrospective analysis was performed on 68 patients with breast cancer treated surgically in wuhan general hospital of guangzhou military in 2014-2015. the breast cancer tissue and the adjacent normal tissue were collected from the patients. quantitative real-time pcr (qrt-pcr) was used to detect the expression levels of mir-21 and mir-210 in the breast cancer and adjacent normal tissues. results: according to qrt-pcr, the expression levels of mir-210 and mir-21 in the breast cancer tissue were significantly higher than those in the adjacent normal tissue (p<0.05), which were significantly correlated with lymph node metastasis, clinical staging and differentiation of patients (p<0.05). mir-21 and mir-210 were sig-nificantly positive correlated in both breast cancer tissues and adjacent normal tissues (r=0.7014, 0.7502, p<0.001). the survival rate in the mir-210 high expression group was significantly lower than that in the mir-210 low expression group (p<0.05), whereas there was no significant difference between the mir-21 high and low expression groups. conclusion: mir-21 and mir-210 are highly expressed in the breast cancer tissue and significantly correlated with lymph node metastasis, clinical staging and differentiation. mir-210, the up-regulated expression of which is related to the poor prognosis of patients with breast cancer, may be a potential prognostic indicator for breast cancer, which can be used to judge the prognosis.