Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet’s Disease

Background: both genetic and environmental factors influence, susceptibility to autoimmune disorders including behcet’s disease (bd). fcrl3 (fc receptor like 3 genes), a novel immunoregulatory gene, has recently been reported as a new promising candidate gene for general autoimmunity. this study was conducted to explore the potential association of fcrl3 polymorphisms with bd. methods: this study was conducted from 2010 to 2015 in tehran university of medical sciences, tehran, iran. four single-nucleotide polymorphisms of fcrl3 (rs7528684, rs11264799, rs945635, and rs3761959) were genotyped in 220 patients and 220 healthy controls. typing of the polymorphisms in this case-control study was carried out using polymerase chain reaction-restriction fragment length polymorphism analysis. results: analysis of the alleles revealed a significantly lower frequency of the a allele at the -169 site (rs7528684) in bd patients compared with that in controls (p=0.000, 66.4% versus 82%, χ2= 30.23). moreover, a significant lower frequency of aa genotype and higher frequency of gg genotype was recorded for rs7528684. there was also relationship between posterior uveitis as a clinical sign of disease and polymorphism of allele a at the -169 site (p=0.015). conclusion: this study revealed a significant difference in both allele and genotype frequency at position -169 of fcrl3 gene between iranian patients with bd and normal subjects. these data suggest fcrl3 gene poly-morphisms might be the autoimmunity risk factor for bd.