a case-control study on the p73 g4a gene polymorphism and susceptibility to breast cancer in an iranian population

Background: the tumor protein p73 (tp73) is a homolog of tp53 family. ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. this study aimed to investigate the association between p73 g4a polymorphism and the risk of breast cancer in a northeastern iranian population. methods: this case-control study was performed on 105 patients who admitted in educational hospitals of mashhad university of medical sciences, iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. pcr-ctpp method was used to investigate the relationship between the p73 g4a polymorphism and the risk of breast cancer. results: there was no significant association between the aa genotype of the p73 g4a polymorphism and breast cancer in case and control groups. although g allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. conclusion: there was no association between g4a p73 polymorphism and the risk of breast cancer in a north-eastern iranian population.