association study between functional polymorphisms of mmp9 gene promoter and multiple sclerosis susceptibility in an iranian population

Background: matrix metalloproteinase-9 (mmp-9) polymorphisms, c−1562 t and -90 (ca) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in ms susceptibility and its development. in the present study, the possible association of mmp-9 polymorphisms in iranian ms patients is studied. methods: association of mmp-9 mentioned gene polymorphisms with ms susceptibility was evaluated in unrelated iranian subjects referred to al-zahra hospital, isfahan, iran during 2014 to 2017. results: -1562 t allele of mmp-9 was associated with increased ms risk. however, we found no overall significant effect of −90 (ca)n repeat on ms susceptibility. conclusion: for as much as mmp-9 molecule is a potential target for ms therapy, to determine whether any of mmp-9 polymorphisms influence ms susceptibility in iranian ms patients or not, concerning the significant influence of t allele on ms susceptibility and the non-significant association regarding ca repeats, further research is needed before proposing any definite conclusion.