Serum Zinc Levels in Children and Adolescents with Type-1 Diabetes Mellitus

Background: there have been very few studies, with contradictory results, on the zinc status of children and adolescents with type-1 diabetes mellitus. the objective of this cross-sectional study was to determine zinc status based on the serum zinc concentration in type-1 diabetic children and adolescents and compare it with that of healthy controls. methods: thirty children and adolescents with type-1 diabetes mellitus, aged 6 to 18 years, and 30 age- and sex-matched healthy controls participated in the study. serum zinc, fasting blood sugar, hemoglobin a1c and serum albumin were measured by flame atomic absorption spectrophotometry, enzymatic colorimetry, ion-exchange chromatography and colorimetry using bromocresol green methods, respectively. results: no statistically significant difference was found in the mean serum zinc concentration between diabetic patients and healthy controls (111.0 ± 3.1 and 107.1 ± 3.8 mg/dl respectively, p= 0.4). no correlations were found between the serum zinc levels and fasting blood sugar, hemoglobin a1c, or the duration of the disease in the patients. conclusion: the zinc levels of diabetic children and adolescents are not noticeably different compared to those of healthy controls and are independent of glycemic control and the duration of the disease.