The -514C/T Polymorphism of Hepatic Lipase Gene among Iranian Patients with Coronary Heart Disease

Background: the t allele of the hepatic lipase (hl) c-514t polymorphism was previously found to be associated with lower plasma hl activity. here, we examined the association between this polymorphism and plasma hdl-cholesterol concentrations in patients with coronary arteries stenosis.methods: we studied 342 subjects undergoing coronary angiography in two groups of non cad (n=146) and cad (n=196). -514c^t polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism (pcr-rflp).results: after adjustment for age, smoking and body mass index, hdl-cholesterol concentrations were significantly higher in men with the c/t&t/t genotype than those with the c/c genotype(mean 38.6 and 34.7 respectively p=0.01). the frequency of t allele in non cad was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in cad subjects. there was no difference in t allele frequency in cad and none cad groups in male and female (p=0.466 and 0.722 respectively).conclusion: -514c^t of lipc gene have a positive effect on hdl-c concentration especially in male gender. however, no difference was determined in frequency of t allele between cad and normal arteries subjects.