Genetic Association Analysis of Dopamine DRD3 Ser9Gly Polymorphism and Schizophrenia in Malay Population

Background: molecular components of the dopamine receptor (drd3) play an important role in the pathophysiology ofschizophrenia (scz). previous studies have demonstrated an association between the drd3 ser9gly polymorphism andscz but the results have been inconclusive.method: in this study, we investigated this controversial association between the ser9gly (a/g) polymorphism and sczusing malay cases-control (261 cases/157 controls) samples. pcr-rflp was performed to genotype the distribution ofthe drd3 ser9gly polymorphism.results: both healthy control and schz patient groups were in of hardy-weinberg equilibrium for the analyzed geneticvariability. there was a significant association between the genotype distribution drd3 polymorphisms and scz (÷2=9.359; df = 2; p = 0.009).conclusion: we believe that further studies are required to examine the association between others dopamine-relatedgenes and the behavioral phenotypes of scz.