association of mmp-2-753c>t and mmp-9-1562c>tpolymorphisms with chronic/aggressive periodontitis risk: a systematic review and meta-analysis

Background: two functional polymorphisms in the matrix metalloproteinase-2 and -9 (mmp-2 and mmp-9) genes may contribute to periodontitis pathogenesis. however, the results were inconsistent and inconclusive. therefore, to clarify precise associations of mmp-2-753 c>t and mmp-9-1562c>t polymorphisms with chronic (cp) and aggressive (agp) periodontitis, we performed a systematic review and meta-analysis. methods: a literature search was conducted using pubmed, google scholar, embase, and web of science databases until 5 july 2017. the data were analyzed with cma software, and risk estimates are expressed as odds ratios (ors) and 95% confidence intervals (95% cis). results: nineteen case-control studies in ten publications with 2089 periodontitis cases and 2345 controls met the criteria. the pooled ors indicated that mmp-2-753c>t and mmp-9-1562c>t polymorphisms were not significantly associated with risk of periodontitis in overall analysis. stratified analyses by ethnicity and periodontitis type indicated that the mmp-9-1562c>t polymorphism showed a significant association with the risk of periodontitis among caucasians and cp/agp subgroup, whereas mmp-2-753c>t polymorphism was significantly associated with periodontitis risk only among asians. conclusion: mmp-2-753c>t and mmp-9-1562c>t polymorphisms may not be associated with risk of periodontitis in overall population. however, mmp-2-753c>t and mmp-9-1562c>t polymorphisms might have influence on the susceptibility of periodontitis by ethnicity.