establishment of the normal reference range of thrombelastogram among the healthy population and pregnants in china

Background: we aimed to establish the reference range of thrombelastogram (teg) for chinese healthy volunteers and pregnant women and analyze the influence factors. methods: blood samples were collected from healthy volunteers and pregnant women at five tertiary hospitals (the third xiangya hospital of central south university, the second xiangya hospital of central south uni-versity, hunan provincial people's hospital, hunan cancer hospital and changsha central hospital) in 2016. the effects of age, gender, blood type, and full-term pregnancy on the reference range of normal teg for healthy volunteers and pregnant women were studied. the specificity of teg in detecting coagulation disor-der. results: for healthy volunteers, the normal ranges of teg parameters were as follows: r, 4.3-9.3 min; k, 1.2-3.2 min; α, 50.2-71.2°; ma, 54.1-71.3 mm; ly30: 0%-2.2%; ci, -3.8-2.4. at least one parameter exceeded the normal range specified by the manufacturer in 20.3% of the healthy volunteers; about 7.6% healthy volunteers were diagnosed as coagulation disorder by the above standards; the specificity of detection was 79.7%. there were significant differences in r, k, α, ma and ci between males and females (p<0.01). for pregnant women, the normal ranges of teg were as follows: r, 3.9-7.5 min; k, 1.0-2.4 min; α, 57.6-74.9°; ma, 55.7-75.7 mm; ly30, 0%-0.56%; ci, -0.97-3.6. pregnant women having o blood group had a dramatically prolonged r. full-term pregnancy had no significant impact on teg results. conclusion: compared with pregnant women having non-o blood group, those having o blood group had a dramatically prolonged r and showed greater tendency to hemorrhage during and after parturition.