Dietary and the Risk of Sporadic Colorectal Cancer in China: A Case-Control Study

Background: high-fat diets have been considered a risk factor for sporadic colorectal cancer (crc) in west-ern countries. however, data for this phenomenon are lacking in china. the purpose of this study was to com-prehensively evaluate the association between diet and the risk for sporadic crc in shandong province, china. methods: in this case-control study, 317 patients with sporadic crc and 317 controls were collected in shan-dong province, china. all the samples were collected on the basis of rigorous screening criteria. the data were analyzed using a χ2 test, univariate or multivariate conditional logistic regression, and stratified analysis. results: multivariate logistic regression showed that the following are risk factors for sporadic crc (all p<0.05): consumption of pork, fried food or barbecued meat; high body mass index (bmi); alcohol abuse; psychosis; and the presence of a factory causing pollution near the home. moreover, univariate analysis revealed the following qualities were also positively associated with crc (all p<0.05): intake of animal oil, consuming brawn and kipper, smoking, exhibiting frequent anger, and poor sleep quality. eating fresh fruit was inversely correlated with the incidence of crc (p=0.012). further stratified analysis demonstrated that bmi and the con-sumption of fried food, barbecued meat, or garlic were correlated with colon cancer. however, alcohol abuse and psychosis were related to an increased risk for rectal cancer. conclusion: dietary factors are related to sporadic crc in shandong province. future interventions should focus on reducing the related risk factors while advocating for practice of the protective factors.