noninfectious causes of fever in 128 patients with systemic lupus erythematosus

Background: this study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (sle) and the underlying causes through multivariate analysis. methods: clinical data of 128 patients with sle who were admitted to affiliated hospital of nanjing universi-ty of tcm, nanjing 210029, p.r. china from january 2015 to december 2017 were retrospectively analyzed. results: the following factors were closely associated with fever: patient age, treatment history, sledai score, enlarged liver, spleen and lymph nodes, low hemoglobin, leukopenia, crp, complement c3, albumin, anti-dsdna antibody, glucocorticoids, and cyclophosphamide. multivariate logistic regression analysis showed that factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leuko-penia, crp, decreased albumin, anti-dsdna antibody, glucocorticoids and cyclophosphamide, were closely as-sociated with noninfectious fever in sle. conclusion: noninfectious fever is a common clinical manifestation of sle. factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, crp, decreased albumin, anti-dsdna antibody, glucocorticoids, and cyclophosphamide, were independent risk factors for noninfectious fever in sle.