haplotype analysis of peroxisome proliferator-activated recep- tor γ gene polymorphisms and the lipoprotein (a) level

Background: lipoprotein (a) [lp(a)], as an independent risk factor for cardiovascular disease, is more likely to be genetically determined according to the increasing evidence of epidemiologic and clinical studies in recent years. peroxisome proliferator-activated receptor (ppar)γ, the ligand-activated transcription factors, was considered as an indispensable role in the process of lipid metabolism. this study was designed to explore the associations of three single-nucleotide polymorphisms (snps) and the haplotypes of the peroxisome proliferatoractivated receptor (ppar)γ gene with the level of lp(a). methods: participants were recruited under the framework of the pmmjs (the prevention of metabolic syndrome (ms) and multi-metabolic disorders in jiangsu province of china study) from apr 1999 to jun 2004. overall, 644 subjects were randomly selected and 3 snps of pparγ gene (rs10865710, rs1805192, rs4684847) were genotyped. results: after adjusting for age, sex, cigarette smoking, alcohol drinking, waist circumference and body mass index, rs4684847 was significantly associated with lp (a). the presence of the rs4684847 t allele (ct+tt) have a lower level of lp (a) than the allele (cc) in the dominant model, mean difference was -27.30 (95%ci:52.88~-1.73) mg/l, p<0.05. g-p-t and g-a-t haplotype were associated with lower levels of lp (a) (p=0.0041 and<0.0001), mean difference was 49.79(95%ci:-97.52~-2.06) mg/l and 17.75(95%ci:-25.75~9.75) mg/l. conclusion: ppar gamma polymorphisms (rs10865710, rs1805192, rs4684847) and haplotypes may be the genetic risk factors for lp (a) level.