HIV CRF08_BC and X4 strain are associated with posing major nucleoside and non-nucleoside reverse transcriptase inhibitors resistance mutations

In hiv treatment,surveillance of mutations inducing resistance to nrtis (nucleoside reverse transcriptase inhibitors) and nnrtis (non-nucleoside reverse transcriptase inhibitors) is important. this study analyzed 2,071 hiv-1 genomic sequences directed to detection of major nrtis and nnrtis resistance mutations and viral tropism. crf08_bc and x4 strain more likely had major nrtis (adjusted odds ratio (aor) 3.0,95% ci 1.182-7.820,p=0.021 and aor 1.7,95% ci 1.233-2.368,p=0.001; respectively) and nnrtis (aor 3.3,95% ci 1.281-8.365,p=0.013 and aor 1.4,95% ci 1.037-1.977,p=0.029,respectively) resistance mutations. subtype a1 (aor 0.2,95% ci 0.069-0.702,p=0.011) and c (aor 0.4,95% ci 0.241-0.648,p<0.001) were associated with major nrtis resistance mutations. the occurrence of major nrtis and nnrtis resistance mutations in hiv subtype a1,c,crf08_bc,and x4 viruses should be a particular concern. © 2015 penerbit utm press. all rights reserved.