Study of specific pharmacological activity of sodium salt (4-O-B-glucopyranosyloxy)-benzoic acid

Chronic inflammatory diseases of various genesis are prevalent today. non-steroidal anti-inflammatory drugs (nsaids) are commonly used to treat pain and inflammation,but their long-term use is associated with complications in the gastrointestinal tract,including peptic ulcers. we synthesized a molecule of sodium salt (4-o-β-glucopyranosyloxy)-benzoic acid. this substance has diuretic and anti-inflammatory activities. it should be noted that most of nsaids has analgesic effect. in this connection,the aim of this study was to evaluate the analgesic activity of sodium salt (4-o-β-glucopyranosyloxy)-benzoic acid. we studied analgesic effect in the test “acetic writhing”. sodium salt (4-o-β-glucopyranosyloxy)-benzoic acid significantly reduces the number of writhing by 14 units during the experiment,as an alternative criterion percent of animals with analgesia was 42.6%. thus,in the test “ acetic writhing” revealed the presence of the analgesic activity have developed drug average severity. © 2016 penerbit utm press. all rights reserved.