Relationship and trend of changes on parathyroid hormone and creatinine level of prenatal ultrasound induced experimental subjects

The aim of this study is to experimentally investigate the effects of prenatal ultrasound exposure on parathyroid hormone and creatinine levels of young rabbit and its trend of changes,and the relationship between parathyroid hormone and creatinine levels of the experimental subjects. a total number of 14 rabbits (oryctolagus cuniculus) served as the model,where seven pregnant rabbits (treated group) were scanned using ultrasound in the middle of pregnancy for 60 minutes,while another seven pregnant rabbits served as negative control group. after delivery term,the newborns resulted from treatment scheme served as the subject of this study. blood samples were withdrawn between the ages of 1 month old to five months old and sent to the lab for parathyroid and creatinine level test. the parathyroid hormone (p=0.019) were significantly reduced and no significant difference in creatinine levels (p=0.485). there were significantly reduced pth in 3 and 5 months old rabbits (p=0.046 and p=0.045,respectively and significantly reduced creatinine level in 2 months old rabbit (p=0.019). correspondingly,there is no significant linear relationship between parathyroid hormone and creatinine levels (p = 0.835). for trend of changes test,a further long-term study should be taken into consideration to test whether prenatal ultrasound exposure might cause the opposite results in the next generation in young age rabbit. © 2016 penerbit utm press. all rights reserved.