Blood glucose level and lipid profile of alloxan–induced diabetic rats treated with na-alginate from seaweed turbinaria ornata (Turner) J.agardh

Diabetes mellitus (dm) is a metabolic disorder due to insulin deficiency,insulin resistance or inability of β-cells of pancreas to produce insulin. this study was aimed to evaluate the effects of na-alginate from turbinaria ornata (turner) j.agardh on glucose level and lipid profile in alloxan?induced diabetic rats. na-alginate was extracted from t. ornata then analyzed by tlc and ftir. in vivo test was performed on alloxan monohydrate induced diabetic rats. in vivo parameters evaluated were body weight,blood glucose and lipid profiles (total cholesterol,hdl-c,ldl-c,and triglyceride). in vivo test was conducted by a complete randomized design with six treatments,0.5 % cmc-na,glibenclamide 5 mg kg–1,na-alginate 200 mg kg–1,na-alginate 400 mg kg–1,na-alginate 600 mg kg–1,and nacl 0.9 % per each five replications. the results showed that na-alginate at 600 mg·kg–1 increased weight of rat significantly comparing to normal control. na-alginate 600 mg kg–1 also lowered preprandial and postprandial glucose better than other doses. increasing dose of na-alginate lowered total cholesterol,increased hdl-c,and lowered ldl-c. the higher dose of alginate gave greater effect on diabetic rats. however,na-alginate did not affect the triglyceride. © 2016 penerbit utm press. all rights reserved.