the correlation between cyp450 ile462val polymorphism and prostate cancer in a group of iranian men

Background: cytochrome p450 plays an important role in pharmaceuticalmetabolism, steroidal hormones and procarcinogens. cyp1a1 is an enzyme, whichis very active in the formation of reactive mediators or injurious agents for dna. theaim of this study is to evaluate the prevalence rate of genetic polymorphism rs1048943 gene cyp1a1 in men diagnosed with prostate cancer compared to a controlgroup of healthy men.methods: this case-control study analysed blood samples from 79 patients withprostate cancer as well as 79 healthy men. genomic dna was extracted by the saltingout method. after selecting the suitable primers from the papers, the samples wereamplified for the considered segment and genotypes of the participants were determinedby pcr-rflp.results: individuals with prostate cancer had the following genotypes: aa (31.64%),gg (59.49%) and ag/ga (8.86%) compared to the control group that had genotypesaa (55.69%), gg (29.11%) and ag/ga (15.18%). according to the hardy–weinbergequilibrium, the frequency of allele a was 36.7% in the cancer group and 63.29% inthe control group. the frequency of allele g was 63.92% in the cancer group and 36.70%in the control group. there were meaningful differences in the frequencies ofhomozygotes gg (p < 0.001) and aa (p=0.002) between patients and controls.conclusion: polymorphism rs 1048943 in gene cyp1a1 is related to the risk ofdeveloping prostate cancer and it is likely one of the major factors in its occurrence.