determination of risk factors affecting survival of patients with gastric adenocarcinoma in hamadan, iran

Background: gastric cancer is the second leading cause of cancer death. the aimof this study was to determine the survival rate affected by risk factors in patients withgastric adenocarcinoma.methods: we performed this retrospective cohort study on patients diagnosedwith gastric adenocarcinoma during 2005-2012 in hamadan, iran. all patients withpathological diagnosis enrolled in the study. the effects of patients’ demographical andpathological data were assessed in terms of survival. the univariate and multivariateweibull models were used to determine the effects of these factors on survival rate. datawas analyzed by spss16 and stata10 software.results: a total of 112 gastric adenocarcinoma patients were followed. patientsincluded 74 (66.1%) males. during the follow-up, 102 (91.1) patients died. patients’had a mean (sd) survival of 21.9 (1.9) months and a median survival of 15 months.the “one-, three- and five-year survival rates were 62%, 16% and 9% respectively. theresults showed that metastasis, chemotherapy, tumor site and grade had statisticallysignificant impacts on patient survival.conclusion: a potentially important role for tumor grade, tumor site, metastasis,and pathologic stage of disease existed in terms of patient survival after surgery. thecurrent research has indicated that neoadjuvant treatment increased survival in patientswith gastric adenocarcinoma. it is expected that the prognostic model based on thementioned factors may assist individual risk stratification and help in the planning ofpotential forthcoming studies.