Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran

Background: phyllodes tumors are uncommon neoplasms of the breast. dataabout their outcome is limited. this study aims to evaluate patients diagnosed withphyllodes tumors in terms of local recurrence, distant metastasis and overall survival.methods: we retrospectively reviewed the medical records of 129 women withphyllodes tumors who referred to our center from 1999 to 2013. clinical and pathologicalfeatures, local and regional recurrence, distant metastasis and overall survival weredetermined. spss 15.0 statistical software was used for analysis.results:mean patient age was 39 years (17-67 years). mean size of the tumor was5.38 cm. there were 105 (81.4%) benign, 8 (6.2%) borderline and 16 (12.4%)malignant tumors. the mean follow-up period of patients was 28 months (6 to 128months). the rate of local recurrence among benign tumors was 3.8% (4 cases); inborderline cases the rate was 12.5% (1 case) and for malignant cases, it was 18.7% (3cases). three patients each recurred twice and one patient had local recurrence for athird time. two patients died of malignant tumor-related disease - one due to advancedregional recurrence and lung metastasis, and the other to wide-spread metastasis.another patient died from an unrelated cause (myocardial infarction) one year aftersurgery. for those with malignant phyllodes tumors, the five-year overall survival was77.8% and disease-free survival rate was 85.7%.conclusion: although, the prognosis for phyllodes tumors is good, the malignancyrate is higher in older patients and those with larger tumors. a higher local recurrencerate in malignant phyllodes tumors suggests the importance for adequate resection ofmargins in surgical management of these tumors.