Relationship between Human Papilloma Virus and Colorectal Cancer in Northern Iran

Background: colorectal cancer is one of the most common malignancies worldwidewith more than one million new cases. according to the ministry of health andmedical education of iran, colorectal cancer is the third most common cancer in iran.many risk factors are known causes of this disease. however, the molecular mechanismsassociated with colorectal cancer are still under investigation. recent studies have shownthat some viruses, particularly human papilloma virus, may be associated with thepathology of colorectal cancer.methods: this case-control study examined 95 colorectal cancer and 95 normalcolon tissue paraffin blocks (control) to identify the relationship between humanpapilloma virus and colorectal cancer by polymerase chain reaction.results: clinicopathological data that included sex, age, tumor grade, stage andlocation were recorded. all tumor and control groups (totally: 190 samples) were negativein terms of the human papilloma virus genome. no relationship between clinicopathologicaldata and human papilloma virus genome was identified.conclusions: regardless of other risk factors for colorectal cancer, a number ofstudies in different parts of the world have shown that human papilloma virus may bean important factor in the increasing incidence of colorectal cancer. however, we havefound no association between human papilloma virus and colorectal cancer in this study.