Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer

Background: interleukin-19, a member of the interleukin-10 family of cytokines,contributes to breast cancer pathogenesis. high interleukin-19 expression in breasttumor tissues is associated with poor clinical outcome. this study aimed to assessthe changes in serum level of interleukin-19 in breast cancer patients in comparisonwith normal women and its association with the clinicopathological parameters ofthis disease.methods: enzyme-linked immunosorbent assay was used to analyze serumlevels of interleukin-19 in 116 women with breast cancer before chemotherapy orradiotherapy, and in 60 healthy age-matched women without any acute or chronicdiseases or family history of cancer.results: there were significantly lower serum interleukin-19 levels in breast cancerpatients (median: 27.3 pg/ml; range: 10.5-2443.6 pg/ml) compared to healthycontrols (median: 35.1 pg/ml; range: 10.9-13676.6 pg/ml; p < 0.01). compared to thehealthy control group, the decrease in serum interleukin-19 concentration was seenin all breast cancer stages. however the decrease was only significant for stage iii(p=0.02). we found no significant association between serum interleukin-19 levelsand stage, grade, lymph node involvement or other clinicopathological variables ofthe disease. however, when compared to the healthy control group, we foundsignificantly decreased serum interleukin-19 levels in patients with involved lymphnodes (p < 0.01) or tumor size greater than 2 cm (p=0.01).conclusion: there were significantly decreased interleukin-19 levels in breastcancer patients compared to the healthy control group. we observed no associationbetween serum interleukin-19 levels and clinicopathological parameters in breastcancer patients.